NANOCRYSTAL CALCIUM PHOSPHATIC MATERIALS INTENDED FOR USE IN THE QUALITY OF FILTERS FOR PROTECTION FROM ULTRAVIOLET RADIATION
Abstract
The prospects article considers materials used as inorganic filters in sunscreens and moisturizers existing on the market, lipsticks and powders. The possibility of using synthetic nanocrystalline materials of calcium phosphate composition in cosmetic sun protection products for replacing inorganic filters of titanium dioxide and zinc oxide, traditionally used as filters for ultraviolet radiation, has been determined. It has been shown that ecological pure synthetic nanocrystalline Ca10(PO4)6(OH)2 powders can be obtained using the methods of “green chemistry” from solutions of Ca(OH)2 and H3(PO4)2 grades of “chemically pure” and “analytically pure” The optimal ratios of the initial components and heat treatment regimes are determined, which ensure the production of a powder with a crystal size of 25 – 50 nm at a Ca/P ratio of 1,67. In the heat treatment of powders (after aging) a coarse-grained crystalline structure is formed, the particle size rises to 75 nm. The skin-irritating and skin-resorptive properties of the developed materials were studied on warm-blooded animals – guinea pigs of the light mask and white laboratory rats on the change in the intensity of biochemiluminescence of whole animal blood and on the changes in the biochemical parameters of blood serum constants of experimental and control animals. When carrying out a full complex of toxicological and hygienic tests in vivo, it is established that the obtained materials do not possess skin-rending properties and are biocompatible with the tissues of the body.
Keywords: synthetic sunscreens, hydroxyapatite, titanium dioxide, inorganic filters, skin irritant, skin-resorbing properties.
References
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